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・ Granieu
・ Graniger
・ Granigyra
・ Granigyra arenosa
・ Granigyra filosa
・ Granigyra granulifera
・ Granigyra limata
・ Granigyra nipponica
・ Granigyra oblatogyra
・ Granigyra piona
・ Granigyra pruinosa
・ Granigyra radiata
・ Granigyra spinulosa
・ Granigyra tenera
・ Granila
Granin
・ Granin (disambiguation)
・ Granini
・ Granisetron
・ Granish
・ Granisle
・ Granit
・ Granit (company)
・ Granit Lekaj
・ Granit oak
・ Granit Taropin
・ Granit Xhaka
・ Granit, Bulgaria
・ Granita
・ Granita (disambiguation)


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Granin : ウィキペディア英語版
Granin

Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles.
== Function ==
Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet settled but there is evidence that granins function as pro-hormones, giving rise to an array of peptide fragments for which autocrine, paracrine, and endocrine activities have been demonstrated in vitro and in vivo. The intracellular biochemistry of granins includes binding of Ca2+, ATP and catecholamines (epinephrine, norepinephrine) within the hormone storage vesicle core. There is also evidence that CgA, and perhaps other granins, regulate the biogenesis of dense-core secretory vesicles and hormone sequestration in neuroendocrine cells.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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