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Gustducin is a G protein associated with taste and the gustatory system, found in some taste receptor cells. Research on the discovery and isolation of gustaducin is recent. It is known to play a large role in the transduction of bitter, sweet and umami stimuli. Its pathways (especially for detecting bitter stimuli) are many and diverse. An intriguing feature of gustducin is its similarity to transducin. These two G proteins have been shown to be structurally and functionally similar, leading researchers to believe that the sense of taste evolved in a similar fashion to the sense of sight. Gustducin is a heterotrimeric protein composed of the products of the GNAT3 (α-subunit), GNB1 (β-subunit) and GNG13 (γ-subunit). == Discovery == Gustducin was discovered in 1992 when degenerate oligonucleotide primers were synthesized and mixed with a taste tissue cDNA library. The DNA products were amplified by the polymerase chain reaction method, and eight positive clones were shown to encode the α subunits of G-proteins, (which interact with G-protein-coupled receptors). Of these eight, two had previously been shown to encode rod and cone α-transducin. The eighth clone, α-gustducin, was unique to the gustatory tissue. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gustducin」の詳細全文を読む スポンサード リンク
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