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Gynecomastia
Gynecomastia is a common disorder of the endocrine system in which there is a non-cancerous increase in the size of breast tissue in males.〔 Most adolescent boys, up to 70%,〔 have some breast development during puberty. Newborn and adolescent males often experience temporary gynecomastia due to the influence of maternal hormones and hormonal changes during puberty, respectively.
The development of gynecomastia is usually associated with benign pubertal changes; in adolescent boys, the condition is often a source of psychological distress. However, 75% of pubertal gynecomastia cases resolve within two years of onset without treatment.〔 In rare cases, gynecomastia has been known to occur in association with certain disease states.〔 Gynecomastia may be seen in individuals with Klinefelter syndrome or certain cancers, with disorders involving the endocrine system or metabolic dysfunction, with the use of certain medications, or in older males due to a natural decline in testosterone production.〔
Disturbances in the endocrine system that lead to an increase in the ratio of estrogens/androgens are thought to be responsible for the development of gynecomastia.〔 This may occur even if the levels of estrogens and androgens are both appropriate but the ratio is altered.〔 The disorder is usually diagnosed by a physician after a detailed history and physical examination. Conservative management of gynecomastia is often appropriate as the condition commonly resolves on its own. Medical treatment of gynecomastia that has persisted beyond two years is often ineffective. Medications such as aromatase inhibitors have been found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz–Jeghers syndrome,〔 but surgical removal of the excess tissue is usually required.〔
==Signs and symptoms==
The classic feature of gynecomastia is male breast enlargement with rubbery or firm glandular subcutaneous chest tissue palpated under the areola of the nipple in contrast to softer fatty tissue.〔 This enlargement may occur on one side or both. Milky discharge from the nipple is not a typical finding, but may be seen in a gynecomastic individual with a prolactin secreting tumor.〔 Males with gynecomastia may appear anxious or stressed due to concerns about the possibility of having breast cancer.〔〔 An increase in the diameter of the areola and asymmetry of chest tissue are other possible signs of gynecomastia.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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