翻訳と辞書
Words near each other
・ HD-4
・ HD-64180
・ HD-MAC
・ HD-Rosetta
・ HD.32
・ HD1 (French TV channel)
・ HD2
・ HD2IOA
・ HD5
・ HD66
・ HDA
・ HDAC1
・ HDAC10
・ HDAC11
・ HDAC3
HDAC4
・ HDAC6
・ HDAC7
・ HDAC8
・ HDAC9
・ Hdaj
・ HDanywhere
・ Hdatta
・ HDAX
・ HDB (disambiguation)
・ HDB gallery
・ HDB/Cram and Ferguson
・ HDBaseT
・ HDBuzz
・ HDC


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HDAC4 : ウィキペディア英語版
HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the ''HDAC4'' gene.
== Function ==
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9759 )〕 Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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