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HEPACAM : ウィキペディア英語版
HEPACAM
Gene ''hepaCAM'', named based on its original site of identification - ''hepa''tocytes and the nature of its protein product - a cell adhesion molecule (''CAM''), was first discovered and characterised in human liver and reported by Shali Shen (MD, PhD) in 2005. The gene encodes a protein of 416 amino acids, designated as hepaCAM, which is a new member of the immunoglobulin superfamily of cell adhesion molecules (IgSF CAM). The main biological functions of hepaCAM include a) modulating cell adhesion and migration, and b) inhibiting cancer cell growth.〔
==Identification of hepaCAM==

Through differential screening of gene expression, over 200 genes were found to be either up- or down-regulated in a hepatocellular carcinoma patient. These genes were subsequently evaluated against a panel of human HCC specimens, leading to the identification of a novel gene ''HepN1''. Based on the sequence of ''HepN1'', the new gene ''hepaCAM'' was then isolated and characterised.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「HEPACAM」の詳細全文を読む



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