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HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human) is a protein that in humans is encoded by the ''ERBB2'' gene, which is also frequently called ''HER2'' (from human epidermal growth factor receptor 2) or ''HER2/neu''.
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.〔
== Name ==
''HER2'' is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. ''Neu'' is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ''ErbB-2'' was named for its similarity to ''ErbB'' (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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