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HH-suite
The HH-suite is an open-source software package for sensitive protein sequence searching. It contains programs that can search for similar protein sequences in protein sequence databases. These sequence searches are a standard tool in modern biology with which the function of unknown proteins can be inferred from their sequence.
==Sequence searches in biology==
Since the sequence of the human genome was determined in 2000, sequencing costs have dropped dramatically. Sequences for thousands of bacteria and hundreds of animals, plants, and fungi are filling the public sequence databases, but few of the functions of all the proteins encoded in these sequences are known. Even out of the approximately 20 000 human proteins, a large fraction of structures and functions remain unknown. To predict the function, structure, or other properties of a protein for which only its sequence of amino acids is known, the protein sequence is compared to the sequences of other proteins in public databases. If a protein with sufficiently similar sequence is found, the two proteins are likely to be evolutionarily related ("homologous"). In that case, they are likely to share similar structures and functions. Therefore, if a sufficiently similar protein with known functions and/or structure can be found by the sequence search, the unknown protein's functions, structure, and domain composition can be predicted. Such predictions greatly facilitate the determination of the function or structure by targeted validation experiments.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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