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HINT2
Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein that in humans is encoded by the ''HINT2'' gene on chromosome 9. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/84681 )〕 ==Structure==
As a member of the histidine triad nucleotide-binding (Hint) protein family, which is a subfamily of the histidine triad (HIT) family, HINT2 contains a conserved histidine and HIT motif (His-X-His-X-His), which carry out its catalytic function.〔〔 The 163-amino acid protein encoded by this gene forms a 17-kDa dimer, though unlike the other Hint members, it is an asymmetric rather than a symmetric homodimer.〔〔〔 Compared to other members of the Hint family, HINT2 has a 61% sequence homology to HINT1 and 28% sequence homology to HINT3.〔 When compared with HINT1, the 35–amino acid extension at the HINT2 N-terminal corresponds to a predicted mitochondria import signal.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「HINT2」の詳細全文を読む
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