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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HIOC ： ウィキペディア英語版 HIOC HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM). It was derived from N-acetylserotonin (NAS).〔〔 Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues).〔〔 It is described as producing long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor.〔 HIOC is systemically-active and is able to penetrate the blood-brain-barrier.〔 In animal studies, HIOC was found to robustly protect against glutamate-induced excitotoxicity, an action which was TrkB-dependent.〔 ==See also== * 7,8-Dihydroxyflavone * Amitriptyline 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HIOC」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.