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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HK3 ： ウィキペディア英語版 HK3 Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the ''HK2'' gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. (by RefSeq, Apr 2009 )〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/3101 )〕 ==Structure== HK3 is one of four highly homologous hexokinase isoforms in mammalian cells. This protein has a molecular weight of 100 kDa and is composed of two highly similar 50-kDa domains at its N- and C-terminals.〔〔〔 This high similarity, along with the and the existence of a 50-kDa hexokinase (HK4), suggests that the 100-kDa hexokinases originated from a 50-kDa precursor via gene duplication and tandem ligation.〔〔 Like with HK1, only the C-terminal domain possesses catalytic ability, whereas the N-terminal domain is predicted to contain glucose and G6P binding sites, as well as a 32-residue region essential for proper protein folding.〔〔 Moreover, the catalytic activity depends on the interaction between the two terminal domains.〔 Unlike HK1 and HK2, HK3 lacks a mitochondrial binding sequence at its N-terminal.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HK3」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.