|
HLA-A *02 (A *02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A *02, the α chain is encoded by the HLA-A *02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. Before this revision, HLA-A *02 was also referred to as HLA-A2, HLA-A02, and HLA-A *2. HLA-A *02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus. The A *02 allele group can code for many proteins; as of December 2013 there are 456 different HLA-A *02 proteins. Serotyping can identify as far as HLA-A *02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). Genes can further be separated by genetic sequencing and analysis. HLAs can be identified with as many as nine numbers and a letter (ex. HLA-A *02:101:01:02N).〔 HLA-A *02 is globally common, but particular variants of the allele can be separated by geographic prominence. ==Serotype== The serotyping for the most abundant A *02 alleles is good. For A *0203, A *0206, A *0207 serotyping is borderline useful. There is a separate serotyping for A203 and A210. As of December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HLA-A*02」の詳細全文を読む スポンサード リンク
|