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High-mobility group protein B1, also known as high-mobility group protein 1 (HMG-1), is a protein that in humans is encoded by the ''HMGB1'' gene. HMG-1 belongs to high mobility group. == Function == Like the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription.〔 After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in interactions with many transcription factors. It also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. Contact with core histones changes the structure of nucleosomes. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol.〔 HMGB1 has been shown to play an important role in helping the RAG endonuclease form a paired complex during V(D)J recombination.〔Ciubotaru, M. "RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes." Nucl. Acids Res. (2013) 41 (4): 2437-2454. doi: 10.1093/nar/gks1294〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HMGB1」の詳細全文を読む スポンサード リンク
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