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HOHMS HOHMS (pronounced "''Homes''") is the medical acronym for "''H''igher-''O''rder ''H''isto''M''olecular ''S''tratification", a term and concept which was first applied to lung cancer research and treatment theory. The HOHMS Paradigm postulates that lung cancer cases can be more effectively treated if different tumors can be rationally classified into more homogeneous groups (or "strata"). These could then be used in randomized clinical trials with maximized potential for detecting significant differences in treatment regimens and other characteristics of the differing variants. Rational stratification under the HOHMS paradigm uses a combination of histological criteria and molecular characteristics of the tumor. ==Origin== The ''HOHMS'' acronym was first applied to lung cancer and further developed in 2003 by Cliff Knickerbocker, Walton Distinguished Doctoral Fellow at the University of Arkansas. The HOHMS Paradigm is the major focus of Knickerbocker's doctoral dissertation.〔Knickerbocker CL. The HOHMS Paradigm: Foundation of a new dynamic lung cancer classification system and treatment strategies. University of Arkansas: Unpublished doctoral dissertation.〕 It has been validated (in part) by subsequent advances in research and clinical practice.〔
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