翻訳と辞書 Words near each other ・ Hoye Site ・ Hoye-Crest ・ Hoyer ・ Hoyer Guitars ・ Hox gene ・ Hox genes in amphibians and reptiles ・ Hoxa ・ Hoxa, Orkney ・ HOXA10-HOXA9 ・ HOXA11 ・ HOXA11-AS1 ・ HOXA13 ・ HOXA2 ・ HOXA3 ・ HOXA4 ・ HOXA5 ・ HOXA6 ・ HOXA7 ・ HOXA9 ・ HOXB1 ・ HOXB13 ・ HOXB13-AS1 ・ HOXB2 ・ HOXB3 ・ HOXB4 ・ HOXB5 ・ HOXB6 ・ HOXB7 ・ HOXB8 ・ HOXB9 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HOXA5 ： ウィキペディア英語版 HOXA5 Homeobox protein Hox-A5 is a protein that in humans is encoded by the ''HOXA5'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3202 )〕 == Function == In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.〔 HoxA5 is controlled, at least in part, by DNA methylation. HoxA5 has been shown to upregulate the tumor suppressor p53 and AKT1 by downregulation of PTEN. Suppression of HoxA5 has been shown to attenuate hemangioma growth. HoxA5 has far-reaching effects on gene expression, causing ~300 genes to become upregulated upon its induction in breast cancer cell lines. HoxA5 protein transduction domain overexpression prevents inflammation shown by inhibition of TNFα-inducible monocyte binding to HUVECs. Comparison of the HoxA5 promoter methylation profile across cell types from the least differentiated (human embryonic stem cells) to the most endothelial-like (human umbilical vein endothelial cells, or HUVECs) shows that the HoxA5 promoter is normally heavily methylated in non-differentiated cells and becomes demethylated as cells differentiate down the endothelial lineage. HoxA5 contains a C-Amp Response Elements (CRE) in its promoter. POL2 and CTCF binding are enriched at the CpG-dense HoxA5 promoter in HUVECs, demonstrating transcriptional activity.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HOXA5」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.