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HSN2
Hereditary sensory neuropathy, type II also known as HSN2 is a protein which in humans in encoded by the ''HSN2''.〔(【引用サイトリンク】 url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=378465 )〕 It is a single-exon ORF, and a nervous system-specific exon of the WNK1 gene. HSN2 is as an alternatively spliced exon of WNK1 and this selectively occurs in nervous tissues, resulting in WNK1/HSN2 nervous system isoforms.〔 ==Function== The WNK1/HSN2 isoforms are expressed in the sensory parts of the peripheral nervous system and central nervous system which are associated with the transmission of sensory and nociceptive signals. These parts include satellite cells, Schwann cells, and sensory neurons. The novel protein product of the isoform is more plentiful in sensory neurons than motor neurons.〔 It is proposed that this gene product may play a role in the development and/or maintenance of peripheral sensory neurons or their supporting Schwann cells.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「HSN2」の詳細全文を読む
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