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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HT-2157 ： ウィキペディア英語版 HT-2157 HT-2157 (former code name SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release,〔(Rowley HL, et al. Effects of HT 2157, a galanin 3 receptor antagonist, on extracellular levels of 5 HT in various brain regions of freely moving rats. ''Proceedings of the British Pharmacological Society'' Winter Meeting December 2005 )〕 as well as producing antidepressant and anxiolytic effects in animal studies,〔Swanson CJ, et al. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. ''PNAS'' 2005; 102(48):17489-17494. doi 10.1073/pnas.0508970102〕 and it was also being researched for treatment of cognitive dysfunction.〔Kaplan AP. Enteric-coated HT-2157 compositions and methods of their use. Patent US 8277842, filed Jan 20th 2012.〕 All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.〔http://www.dartneuroscience.com/DrugPrograms.php〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HT-2157」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.