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・ Hury
・ Hury Reservoir
・ Hurz
・ Hurşit
・ Hurşit Atak
・ Hurşit Güneş
・ Hurşit Tolon
・ Hurşut Meriç
・ Hus
・ Hus (surname)
・ Hus family
・ Hus Gallery
・ Hus language
・ Hus' House (Vinohrady)
・ Hus' House (Vršovice)
HUS1
・ Husa
・ Husa Transportation Group
・ Husab Mine
・ Husaberg
・ Husaby
・ Husafell Stone
・ Husaibah Al Sharqiah
・ Husain
・ Husain Abdullah
・ Husain Ahmad Madani
・ Husain al-Radi
・ Husain al-Rahhal
・ Husain Ali
・ Husain Ali Khan


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HUS1 : ウィキペディア英語版
HUS1

Checkpoint protein HUS1 is a protein that in humans is encoded by the ''HUS1'' gene.
== Function ==

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3364 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「HUS1」の詳細全文を読む



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