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Hadrucalcin
Hadrucalcin is a peptide toxin from the venom of the scorpion ''Hadrurus gertschi''.〔http://www.uniprot.org/uniprot/B8QG00〕 Hadrucalcin modifies the Ryanodine receptor channels RyR1 and RyR2, found in the sarcoplasmic reticulum, to a long-lasting subconductance state, thus inducing the release of calcium from the sarcoplasmic reticulum.〔Schwartz EF, Capes EM, Diego-García E, et al. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors. Br J Pharmacol. 2009;157(3):392-403. doi:10.1111/j.1476-5381.2009.00147.x.〕 ==Source and Etymology== Hadrucalcin (alternative spelling: Hadrucalcine, short name: HdCa) is obtained from the venom gland of the scorpion ''Hadrurus gertschi'',〔 endemic to Guerrero, Mexico.〔Soleglad ME. The Taxonomy of the Genus Hadrurus Based on Chela Trichobothria (Scorpionida: Vejovidae). J Arachnol. 1976;3:113-134. doi:10.2307/3705291.〕 Hadrucalcin is named after the scorpion that produces the peptide and its similarity to other toxins of the scorpion calcine family.〔
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