| 翻訳と辞書 |
Hairless
Hairless, also known as H, is a well-characterized Drosophila gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=Gene&Term=42445 )〕 Many mutations to hairless are embryonic lethal; however, there are several viable hairless mutants.〔(【引用サイトリンク】 url = http://flybase.org/reports/FBgn0001169.html )〕 Hairless is involved in the Notch signaling pathway in Drosophila, acting as a suppressor of Notch signaling.
== Summary ==
Hairless (H) is a protein which is hydrophilic.〔Paz-Gomez, D., Baizabal-Aguirre, V. M., Valdez-Alarcón, J., Cajero-Juárez, M., Nagel, A., Preiss, A., Maier, D., Bravo-Patiño, A. (2008). Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein. International Journal of Biological Macromolecules, 43 (5). 426-432 doi: 10.1016/j.ijbiomac.2008.08.012〕" The protein is composed of “1076 amino acids, with a molecular weight of 110 kDa.〔” The H protein is reported in insects and is found in nearly all of the Drosophilidae family.〔 According to Paz-Gomez et al. (2008), other insect families and orders containing the H protein include the Culicidae family as well as the Lepidoptera, Hymenoptera and Coleoptera orders.
By referencing the research of Paz-Gomez et al. (2008), one finds that in Drosophilia, NSP, or Notch Signaling Pathway, allows for communication intercellularly during embryo development and also physiological activities of adult organisms. Their research also states that Notch Signaling Pathways turn on periodically during devolvement to help determine cell fate functions of the cell. Hairless (H) is an antagonist of the NSP as well as a “key member of the Su() repressor complex.〔" Because of this connection, Hairless plays a very important part of embryo development in insects as it helps influence cell fate decisions during this time.〔" It is crucial that proteins, HP120 and HP150, are present as they control normal activity of H.〔 This activity regulation also controls NSP, which allows the fly embryos to develop correctly and any fluctuation in the pathway or proteins can change outcome of the offspring.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Hairless」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|