|
|Section2= |Section3= }} Helenalin is a sesquiterpene lactone found in ''Arnica montana'' and ''Arnica chamissonis foliosa''. Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with ''Arnica''.〔(【引用サイトリンク】title=Poisonous Plants: Arnica montana )〕 If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract. ==Pharmacology== Helenalin has a variety of observed effects ''in vitro'' including anti-inflammatory and antitumor activities. Helenalin has been shown to selectively inhibit the transcription factor NF-κB, which plays a key role in regulating immune response, through a unique mechanism. ''In vitro'', it is also a potent, selective inhibitor of human telomerase—which may partially account for its antitumor effects—has anti-trypanosomal activity, and is toxic to ''Plasmodium falciparum''. Animal and ''in vitro'' studies have also suggested that helenalin can reduce the growth of ''Staphylococcus aureus'' and reduce the severity of ''S. aureus'' infection. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Helenalin」の詳細全文を読む スポンサード リンク
|