|
A hemichrome (FeIII) is a form of low-spin methemoglobin (metHb). Hemichromes, which precede the denaturation processes of haemoglobin (Hb), are mainly produced by partially denaturated haemoglobins and form histidine complexes. Hemichromes are usually associated with blood disorders. == Types of hemichromes == Hemichromes can be classified in two main categories: ''reversible'' and ''irreversible''. Reversible hemichromes (Hch-1) have the ability to return to their native formation (haemoglobin). Some hemichromes can be reduced to the high-spin state of deoxyhaemoglobin, while others are first being reduced to hemochromes (FeII) and then to deoxyhaemoglobin through anaerobic dialysis. Photolysis, in the presence of oxygen from CO and its reaction with the hemochrome, can quickly convert a hemichrome to oxyhaemoglobin (HbO2).〔Molchanova, T. http://www.tatianamolchanova.com/files/Hemichrome_alphaHb_AHSP_Molchanova.pdf〕 Irreversible hemichromes (Hch-2) cannot be converted to their native form. Both the reversible and irreversible hemichromes have a similar rate during proteolytic degradation and they both have a lower percentage of alpha helixes.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hemichrome」の詳細全文を読む スポンサード リンク
|