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Hexane-2,5-dione
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Hexane-2,5-dione : ウィキペディア英語版
Hexane-2,5-dione

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Hexane-2,5-dione is an aliphatic diketone. It is a toxic metabolite of hexane and of 2-hexanone.
==Symptoms==
The initial symptoms of chronic hexane toxicity, attributable to hexane-2,5-dione, are tingling and cramps in the arms and legs, followed by general muscular weakness. In severe cases, atrophy of the skeletal muscles is observed, along with a loss of coordination and problems of vision.〔 Couri D, Milks M. "Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione" Annual Rev. Pharmacol. Toxicol. 1982;22:145-66. 〕
Similar symptoms are observed in animal models. They are associated with a degeneration of the peripheral nervous system (and eventually the central nervous system), starting with the distal portions of the longer and wider nerve axons.

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