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Huntingtin-interacting protein 1
Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.
Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a domain homologous to the death effector domains (DED) found on proteins involved in apoptosis. It is believed that accumulation of high levels of the free form of this protein (free as in dissociated from the huntingtin and free to bind other key protein(s)) in the cell is one of the mechanisms by which neuron cell death is caused in Huntington's Disease (via the caspase-3 route). The role of Hip-1 in caspase mediated cell death remains unclear.
== Discovery ==
Huntingtin interacting protein 1 (HIP1) was first identified by Wanker et al. in 1997.〔 〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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