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Histrionicotoxin
Histrionicotoxins are a group of related toxins found in the skin of poison frogs from the Dendrobatidae family, notably Oophaga histrionica, which are native to Colombia. It is likely that, as with other poison frog alkaloids, histrionicotoxins are not manufactured by the amphibians, but absorbed from insects in their diet and stored in glands in their skin. They are notably less toxic than other alkaloids found in poison frogs, yet their distinct structure acts as a neurotoxin by non-competitive inhibition of nicotinic acetylcholine receptors.
==History==
The first record of histrionicotoxins dates to 1823 by Captain Charles Stuart Cochrane. Cochrane was exploring the tropical rainforests around Colombia and Panama. His reports mention tribes of Indians who used poison tipped arrows and blowgun darts for hunting and war. Upon further exploration, Cochrane found that these Indians extracted the poison from the skins of the poison dart frog, Dendrobates histrionicus. An account from his diary reads:
"() called rana de veneno by the Spanish, about three inches long, yellow on the back, with very large black eyes....those who use poison catch the frogs in the woods and confine them in a hollow cane where they regularly feed them until they want the poison, when they take the unfortunate reptile and pass a pointed piece of wood down his throat and out of one of his legs. This torture makes the poor frog perspire very much, especially on the back, which becomes covered in a white froth; this is the most powerful poison that he yields, and in this they dip or roll the tips of their arrows, which will preserve their destructive power for a year. Afterwards, below this white substance, appears a yellow oil, which is carefully scraped off, and retains its deadly influence for four to six months, according to the goodness (as they say) of the frog. By this means, from one frog sufficient poison is obtained for about fifty arrows."
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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