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Homoplasmy
Homoplasmy is a term used in genetics to describe a eukaryotic cell whose copies of mitochondrial DNA are all identical.〔(Heteroplasmy vs. Homoplasmy. ) University of Miami Faculty of Medicine. Accessed October 21, 2012.〕 Homoplasmic mitochondrial DNA copies may be normal or mutated.〔 Most mutations are heteroplasmic〔Ballana, E., Govea, N., de Cid, R., Garcia, C., Arribas, C., Rosell, J. and Estivill, X. (2008), Detection of unrecognized low-level mtDNA heteroplasmy may explain the variable phenotypic expressivity of apparently homoplasmic mtDNA mutations. Hum. Mutat., 29: 248–257. doi: 10.1002/humu.20639. Accessed October 21, 2012.〕 (only occurring in some copies of mitochondrial DNA) but it has been discovered that homoplasmic mitochondrial DNA mutations may be found in human tumours.〔Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG. "High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection." ''Nature Genetics'' 28, 2001 Jun; pp. 147-50. DOI 10.1038/88859. Accessed October 21, 2012.〕 The term may also refer to uniformity of plant plastid DNA, whether occurring naturally or otherwise. ==See also==
*Heteroplasmy *Microheteroplasmy
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Homoplasmy」の詳細全文を読む
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