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IBMX
|Section2= |Section3= }} IBMX, 3-isobutyl-1-methylxanthine, like other methylated xanthine derivatives, is both a # competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis, and reduces inflammation and innate immunity 〔 and # nonselective adenosine receptor antagonist. As a phosphodiesterase inhibitor, IBMX has IC50 = 2-50 μM and does not inhibit PDE8 or PDE9.〔Soderling and Beavo ''Current Opinion in Cell Biol.'' 2000 12 174〕 ==References== 〔
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