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ICP8 ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of dsDNA;〔 its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent.〔 In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8. ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme. ==See also==
*Virus *Virology
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「ICP8」の詳細全文を読む
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