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IFFO1
IFFO1 (Intermediate Filament Family Orphan 1) is a protein that in humans is encoded by the ''IFFO1'' gene. IFFO1 has uncharacterized function and a weight of 61.98 kDa.〔http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFFO1&search=980676c18c9bbc13207ea102fa1cb9a9〕 IFFO1 proteins play an important role in the cytoskeleton and the nuclear envelope of most eukaryotic cell types.〔http://www.annualreviews.org.ezp2.lib.umn.edu/doi/abs/10.1146/annurev.bi.57.070188.003113〕 ==Gene== IFFO in human is located on the minus strand at Chromosome 12p13.3. The protein contains 17,709 nucleotide bases that encodes for 570 amino acids. The basal isoelectric point is 4.83.〔http://www.phosphosite.org〕 ''IFFO1'' contains a highly conserved filament domain that spans 299 amino acids from amino residue 230 to 529.〔http://www.ncbi.nlm.nih.gov/protein/XP_006719036.1〕 This region has been identified as pfam00038 conserved protein domain family.〔http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00038〕 Due to alternative splicing, there are 7 isoforms of IFFO1 in humans with 10 typical coding exons.
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