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Interleukin 8 receptor, beta
Interleukin 8 receptor, beta is a chemokine receptor. ''IL8RB'' is also known as ''CXCR2'', and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.
== Function ==
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled〔(【引用サイトリンク】url=http://bioinformatics.biol.uoa.gr/gpDB/gpcrview.jsp?id=630 )〕). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, ''IL8RA'', a gene encoding another high affinity IL8 receptor, and ''IL8RBP'', a pseudogene of ''IL8RB'', form a gene cluster in a region mapped to chromosome 2q33-q36.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3579 )〕
Mutations in CXCR2 cause .
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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