翻訳と辞書 Words near each other ・ Iretama ・ Irete ・ Ireti Doyle ・ Ireton (surname) ・ Ireton, Iowa ・ Ireton, Nova Scotia ・ Iretron ・ IReview ・ Ireviken event ・ Irevna ・ Irewe ・ Irewole ・ IREX ・ Irezumi ・ IRF ・ IRF1 ・ IRF2 ・ IRF3 ・ IRF4 ・ IRF5 ・ IRF6 ・ IRF7 ・ IRF8 ・ IRF9 ・ Irfan ・ Irfan (actor) ・ Irfan (band) ・ Irfan (disambiguation) ・ Irfan (name) ・ Irfan Abidi Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク IRF1 ： ウィキペディア英語版 IRF1 Interferon regulatory factor 1 is a protein that in humans is encoded by the ''IRF1'' gene. == Function == Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins. Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300. IRF-1 has been shown to play roles in the immune response, regulating apoptosis, DNA damage and tumor suppression.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3659 )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「IRF1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.