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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク IRGs ： ウィキペディア英語版 IRGs Immunity Related Guanosine Triphosphatases or IRGs are proteins activated as part of an early immune response. IRGs have been described in various mammals but are most well characterized in mice. IRG activation in most cases is induced by an immune response and leads to clearance of certain pathogens. ] ==Background== Interferon (IFN)-inducible GTPases encompass four families of proteins including myxovirus resistant proteins (Mx), guanylate-binding proteins (GBP), immunity-related GTPase proteins (IRGs), and very large inducible GTPase proteins (VLIG). IRGs confer resistance from vacuolar pathogens by localizing to and disrupting the phagocytic vacuole during infection. The activation of IRGs in mice is induced by interferon. IRG genes have been identified in various vertebrates and some invertebrates. They are involved in important immune defenses against intracellular pathogens and as a result have become a target for immune evasion by those pathogens. The intracellular protozoan parasite ''Toxoplasma gondii'' has been shown to target IRGs in mice allowing for resistance from the host immune response. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「IRGs」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.