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・ Irwin, Ohio
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IRX1
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IRX1 : ウィキペディア英語版
IRX1

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the ''IRX1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79192 )〕 All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning.〔 ''IRX1'' has also been shown to act as a tumor suppressor gene in several forms of cancer.
== Role in development ==

''IRX1'' is a member of the Iroquois homeobox gene family. Members of this family play multiple roles during pattern formation in embryos of numerous vertebrate and invertebrate species.〔 IRO genes are thought to function early in development to define large territories, and again later in development for further patterning specification.〔 Experimental data suggest roles for IRX1 in vertebrates may include development and patterning of lungs, limbs, heart, eyes, and nervous system.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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