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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク ISRIB ： ウィキペディア英語版 ISRIB ISRIB, (an acronym for Integrated Stress Response inhibitor), is an experimental drug which reverses the effects of eIF2α phosphorylation with an IC50 of 5nM. It was discovered by a group at the University of California through a semi-automated screening of a large library of small molecules. Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active ''in vivo'', and was found to readily cross the blood-brain barrier, with a half-life of 8 hours. Subsequent testing found ISRIB to produce significant nootropic effects in mice, as measured by enhancement of spatial and fear-associated learning in standard water maze and conditioned environment tests. ==See also== * Meclofenoxate * Salubrinal 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ISRIB」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.