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Ilepcimide : ウィキペディア英語版
Ilepcimide

Ilepcimide, also known as antiepilepserine, is a piperidine anticonvulsant. It was synthesized by Chinese researchers as an analogue of piperine, the main alkaloid and phytochemical of black pepper (and of other plants in the ''Piperaceae'' family), which has been used in the treatment of epilepsy in traditional Chinese medicine and as a nerve tonic in traditional Iranian medicine.
Ilepcimide has serotonergic activity.〔〔Liu, G.Q., Algeria, S., Ceci, A., Gerattini, S., Gobi, M. and Murai, S. (1984) Stimulation of serotonin synthesis in rat brain after antiepilepserine, an antiepileptic piperine derivative. ''Biochemical Pharmacology'' 33:3883-3886〕〔Yan, Q.S., Mishra, P.K., Burger, R.L., Bettendorf, A.F., Jobe, P.C. and Dailey J.W. (1992) Evidence that carbamazepine and antiepilepserine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. ''J. Pharm & Exp Therap.'' 261(2):652-659〕
==Synthesis==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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