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Immunogenicity is the ability of a particular substance, such as an antigen or epitope, to provoke an immune response in the body of a human or animal. In other words, immunogenicity is the ability to induce a humoral and/or cell mediated immune response. The ability of an antigen to elicit immune responses is called immunogenicity, which can be humoral and/or cell-mediated immune responses. Differentiation has to be made between wanted and unwanted immunogenicity. * Wanted immunogenicity is typically related with vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen (virus, bacteria...) aiming at protecting the organism. Vaccine development is a complex multistep process, immunogenicity being at the center of the vaccine efficiency. * Unwanted immunogenicity is an immune response by an organism against a therapeutic antigen (ex. recombinant protein, or monoclonal antibody). This reaction leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. The prediction of the immunogenic potential of novel protein therapeutics is thus a challenge in biotherapy. == Antigenic immunogenic potency == Proteins are significantly more immunogenic than polysaccharides. T cell response is required to drive immunogenicity. Since lipids and nucleic acids are non-immunogenic haptens, they require conjugation with an epitope such as a protein or polysaccharide before they can evoke an immunologic response. * Proteins or polysaccharides are used for studies of humoral immune response. * Only proteins can serve as immunogens for cell-mediated immunity. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Immunogenicity」の詳細全文を読む スポンサード リンク
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