翻訳と辞書 Words near each other ・ Isoparce ・ Isoparce broui ・ Isoparce cupressi ・ Isopavine ・ Isopeda ・ Isopeda villosa ・ Isopenicillin N epimerase ・ Isopenicillin N N-acyltransferase ・ Isopenicillin N synthase ・ Isopentane ・ Isopentenyl phosphate kinase ・ Isopentenyl pyrophosphate ・ Isopentenyl pyrophosphate isomerase ・ Isopentenyl-diphosphate delta isomerase ・ Isopentenyl-diphosphate Delta-isomerase ・ Isopeptag ・ Isopeptide bond ・ Isoperimetric dimension ・ Isoperimetric inequality ・ Isoperimetric point ・ Isoperimetric problem ・ Isoperimetric ratio ・ Isoperla ・ Isoperla carbonaria ・ Isoperla claudiae ・ Isoperlinae ・ Isophlebia ・ Isophorone ・ Isophorone diisocyanate ・ Isophrictis Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Isopeptag ： ウィキペディア英語版 Isopeptag Isopeptag is a 16 amino acid peptide tag that can be genetically linked to proteins without interfering with protein folding.〔(and Howarth,M. (2010). Spontaneous intermolecular amide bond formation between side chains for irreversible peptide targeting. J. Am. Chem. Soc. 132, 4526-4527. )〕 What makes the isopeptag different from other peptide tags is that it can bind its binding protein through a permanent and irreversible covalent bond. Other peptide tags generally bind their targets through weak non-covalent interactions, thus limiting their use in applications where molecules experience extreme forces. The isopeptags covalent binding to its target overcomes these barriers and allows target proteins to be studied in harsher molecular environments. == Development == The isopeptag was developed by dissecting the pilin protein (Spy0128) from ''Streptococcus pyogenes''. Spy0128 contains two intramolecular isopeptide bonds,〔Kang,H.J., Coulibaly,F., Clow,F., Proft,T., and Baker,E.N. (2007). Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science 318, 1625-1628.〕 and to generate the isopeptag one of these bonds was split by removing the last β-sheet in the protein. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Isopeptag」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.