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Isovaleramide : ウィキペディア英語版
Isovaleramide

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Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.
==Occurrence and biological activity==
Isovaleramide is a constituent of valerian root.
In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages.〔"Use of isovaleramide as a mild anxiolytic and sedative agent", 〕 Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported of greater than 400 mg/kg when administered intraperitoneally in mice.
It is a positive allosteric modulator of the GABAA receptor, similarly to isovaleric acid.


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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