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JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It was the most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman, several years after the family was initially described with the discovery of the N-morpholinylethyl compounds pravadoline (WIN 48,098), WIN 55,225 (JWH-200) and WIN 55,212-2 by the Sterling Winthrop group.〔 〕 Several other N-alkyl substituents were found to be active by Huffman's team including the ''n''-butyl, ''n''-hexyl, 2-heptyl and cyclohexylethyl groups,〔Huffman JW, Dong D. Design, Synthesis and Pharmacology of Cannabimimetic Indoles. ''Bioorganic and Medicinal Chemistry Letters''. 1994;4(4):563-566.〕 but it was subsequently determined that the 2-methyl group on the indole ring is not required for CB1 binding, and tends to increase affinity for CB2 instead.〔 〕 Consequently, the 2-desmethyl derivative of JWH-007, JWH-018 has slightly higher binding affinity for CB1, with an optimum binding of 9.00nM at CB1 and 2.94nM at CB2, and JWH-007 displayed optimum binding of 9.50nM at CB1 and 2.94nM at CB2.〔 〕 == Law == JWH-007 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.〔(Swedish Code of Statutes Regulation (2010:1086). )〕〔(Swedish Code of Statutes Regulation (2010:1086). (pdf) )〕 JWH-007 is illegal in Poland since 08.06.2010 on the basis of 'Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii' published in Dz.U. 2011 nr 105 poz. 614〔(【引用サイトリンク】url=http://isap.sejm.gov.pl/DetailsServlet?id=WDU20111050614 )〕 As of October 2015 JWH-007 is a controlled substance in China. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「JWH-007」の詳細全文を読む スポンサード リンク
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