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JWH-018
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678〔(【引用サイトリンク】title=Department of Justice :: Drug Enforcement Administration )〕 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of THC, a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as "legal cannabis herbal incense blends" which in some countries are sold legally as "incense", labeled "not for human consumption".
== History ==
John W. Huffman, an organic chemist at Clemson University, synthesized analogues and metabolites of Δ9-tetrahydrocannabinol (THC), the principal active component of cannabis. JWH-018 is one of these analogues, with studies showing an affinity for the cannabinoid (CB1) receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown.〔(【引用サイトリンク】title=Clemson University :: Department of Chemistry )〕
On December 15, 2008, it was reported by the German pharmaceutical company THC Pharm that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense in a number of countries around the world since 2002.〔(Gefährlicher Kick mit Spice ) 〕〔(Erstmals Bestandteile der Modedroge "Spice" nachgewiesen ) 〕〔(Spice enthält chemischen Wirkstoff ) 〕 An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the compound had been replaced with JWH-073.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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