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Simvastatin/sitagliptin
Simvastatin/sitagliptin (brand name Juvisync) is a fixed-dose combination drug consisting of sitagliptin and simvastatin. Sitagliptin is a dipeptidyl peptidase-4 inhibitor used to treat type 2 diabetes and simvastatin is an HMG-CoA reductase inhibitor used to treat hypercholesterolemia.〔(【引用サイトリンク】 FDA Approves Juvisync, Combination of Sitagliptin and Simvastatin )〕 These two disorders commonly occur in patients at the same time, and have been typically treated with administration of these two drugs in separate tablets. The combination was approved in 2011 and is marketed as Juvisync by Merck. Juvisync was later removed from the market in 2013 due to business reasons.〔(【引用サイトリンク】 Drugs to be Discontinued )〕
==History==
In 1991, Merck & Co’s simvastatin was approved as an HMG-COA inhibitor to lower the levels of LDL cholesterol. In 2006, Merck & Co’s sitagliptin was approved by the FDA for treatment of diabetes mellitus type 2. The patent for simvastatin expired in 2006 and many companies began to create a generic product of simvastatin. By creating a combined-dosage form of simvastatin and sitagliptin, Merck was able to increase their sales of simvastatin while meeting the need of patients who take both simvastatin and sitagliptin.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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