翻訳と辞書
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・ KIR
・ Kir (cocktail)
・ Kir (river)
・ Kir Bulychev
・ Kir Fard
・ Kir Ianulea
・ Kir Lake
・ Kir of Moab
・ Kir Royal
・ Kir Royal – Aus dem Leben eines Klatschreporters
・ Kir Stefan the Serb
・ Kir'Shara
・ Kir-Balar language
・ Kir2.1
・ Kir2.6
KIR2DL1
・ KIR2DL4
・ KIR2DS1
・ KIR2DS4
・ KIR3DL1
・ KIR3DL2
・ KIR3DL3
・ Kir6.2
・ Kira
・ Kira (Belgian singer)
・ Kira (Bhutan)
・ Kira (German singer)
・ Kira (given name)
・ Kira Borisovna Povarova
・ Kira Bousloff


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KIR2DL1 : ウィキペディア英語版
KIR2DL1

Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the ''KIR2DL1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802 )
== Function ==

Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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