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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク KaiC ： ウィキペディア英語版 KaiC ''kaiC'' is a gene belonging to the ''kaiABC'' gene cluster. The ''kaiABC'' gene cluster is a group of genes, consisting of ''kaiA, kaiB, ''and ''kaiC,'' globally regulating circadian gene expression in cyanobacteria. Regulation of ''kaiABC'' expression is essential for circadian rhythmicity, and is particularly important for regulating cyanobacteria processes such as nitrogen fixation, photosynthesis, and cell division.〔Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson C R, Tanabe A, Golden S S, Johnson C H, Kondo T. (1998) Science 281:1519–1523〕 Using bacterial luciferase as a reporter for gene expression, studies have shown that, similar to Drosophila, mouse, and Neurospora clock models, the cyanobacteria circadian clock, controlled by ''kaiABC'' regulation, is also based on a transcription translation feedback loop(TTFL).〔 Within its gene cluster, ''kaiC'' codes for the regulator, KaiC protein, which not only suppresses ''kaiBC ''when overexpressed,'' ''but also suppresses circadian expression of all genes in the cyanobacterial genome.〔Nakahira, Y., Katayama, M., Miyashita, H., Kutsuna, S., Iwasaki, H., Oyama, T., & Kondo, T. Global gene repression by KaiC as a master process of prokaryotic circadian system. PNAS. 2004 January; 101(3): 881-885.〕 == History == Though the ''kaiABC'' gene cluster has been found to exist only in cyanobacteria, evolutionarily ''kaiC'' contains homologs that occur in Archaea and Proteobacteria. It is the oldest circadian gene that has been discovered in prokaryotes. ''kaiC'' has a double-domain structure and sequence that classifies it as part of the ''RecA'' gene family of ATP-dependent recombinases.〔 Based on a number of single-domain homologous genes in other species, ''kaiC'' is hypothesized to have horizontally transferred from Bacteria to Archaea, eventually forming the double-domain ''kaiC'' through duplication and fusion. ''kaiC'''s key role in circadian control and homology to ''RecA'' suggest its individual evolution before its presence in the ''kaiABC'' gene cluster.〔Dvornyk, V. (2003) Origin and evolution of circadian clock genes in prokaryotes. PNAS 100:2495-2500〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「KaiC」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.