翻訳と辞書
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・ L-2 visa
・ L-2-amino-4-chloropent-4-enoate dehydrochlorinase
・ L-2-hydroxycarboxylate dehydrogenase (NAD+)
・ L-3 Aviation Recorders
・ L-3 Communication Combat Propulsion Systems
・ L-3 Communications
・ L-3 Flight International Aviation
・ L-3 Network Security
・ L-3 SmartDeck
・ L-3-cyanoalanine synthase
・ L-368,899
・ L-371,257
・ L-655,708
・ L-687,384
・ L-694247
L-733,060
・ L-741,626
・ L-745,870
・ L-759,633
・ L-759,656
・ L-765,314
・ L-838,417
・ L-ACOUSTICS
・ L-allo-threonine aldolase
・ L-amino-acid alpha-ligase
・ L-amino-acid dehydrogenase
・ L-amino-acid oxidase
・ L-aminoadipate-semialdehyde dehydrogenase
・ L-AP4
・ L-arabinitol 2-dehydrogenase


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L-733,060 : ウィキペディア英語版
L-733,060

L-733,060 is a drug developed by Merck, Sharpe & Dohme which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.
L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury. It also has anticancer effects in a variety of ''in vitro'' models.
== See also ==

* Aprepitant
* Casopitant
* Fosaprepitant
* Maropitant
* Vestipitant
* Vofopitant

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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