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Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the ''LAMP1'' gene. The human ''LAMP1'' gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34). Lysosomal-associated membrane protein 1 is a glyoprotein from a family of Lysosome-associated membrane glycoproteins.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3916 )〕 The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types.〔(【引用サイトリンク】 LAMP1 )〕 It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands.〔 CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.〔(【引用サイトリンク】 work = Wikigenes )〕 and may also play a role in tumor cell differentiation and metastasis. == Structure == Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail〔 exposed to the cytoplasm.〔 The extracytoplasmic region contains a hinge-like structure which can form disulphide bridges homologous to those observed in human immunoglobulin A.〔 Other characteristics of the structure of the LAMP-1 glycoproteins include: * A polypeptide core of ~40kDa〔 * 18 sites to help with the addition of sugar chains * Polyactosamine attachments which protect the glyocoprotein from degradation by lysosomal proteases〔 * Significant quantities of polylactosaminoglycan and sialic acid to traverse the trans-Golgi cisternae.〔 * poly-N-acetyllactosamines groups which are involved in interactions with selectin and other glycan-binding proteins 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「LAMP1」の詳細全文を読む スポンサード リンク
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