翻訳と辞書 Words near each other ・ Larga River (Humor) ・ Larga River (Lotru) ・ Larga River (Suciu) ・ Larga River (Trotuș) ・ Larga Valley ・ Larga vida al Rock and Roll ・ Larga Vista, Texas ・ Larga, Briceni ・ Largan ・ Largan Precision ・ Largan, Chalus ・ Largan, Isfahan ・ Largan, Nowshahr ・ Largario ・ Largdasht ・ LARGE ・ Large ・ Large (film) ・ Large (surname) ・ Large Aden gerbil ・ Large aircraft ・ Large and complex financial institutions ・ Large and small entities in patent law ・ Large Angle and Spectrometric Coronagraph ・ Large Animal Games ・ Large Aperture Experiment to Detect the Dark Ages ・ Large Apparatus studying Grand Unification and Neutrino Astrophysics ・ Large Arch ・ Large Area Neutron Detector ・ Large as Life and Twice as Natural Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク LARGE ： ウィキペディア英語版 LARGE Glycosyltransferase-like protein LARGE1 is an enzyme that in humans is encoded by the ''LARGE'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9215 )〕 == Function == This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. The exact function of LARGE, a golgi protein, remains uncertain. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.〔 LARGE may also play a role in tumor-specific genomic rearrangements. Mutations in this gene may be involved in the development and progression of meningioma through modification of ganglioside composition and other glycosylated molecules in tumor cells. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「LARGE」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.