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Lobular carcinoma in situ
Lobular carcinoma ''in situ'' (LCIS) is a condition caused by unusual cells in the lobules of the breast.〔(【引用サイトリンク】title=Lobular Carcinoma in situ (LCIS) )〕
Many do not considered it cancer, but it can indicate an increased risk of future cancer.〔(【引用サイトリンク】title=Lobular carcinoma in situ: Marker for breast cancer risk )〕〔(【引用サイトリンク】title=Breast Cancer Treatment )〕 The national database registrars, however, consider it a malignancy.
Unlike ductal carcinoma ''in situ'' (DCIS), LCIS is not associated with calcification, and is typically an incidental finding in a biopsy performed for another reason. LCIS only accounts for about 15% of the ''in situ'' (ductal or lobular) breast cancers.〔(【引用サイトリンク】title=Susan G. Komen for the Cure | Understanding Breast Cancer | Breast Facts | Statistics | Breast Cancer Statistics )〕
==Genetics==
Cells of LCIS and invasive lobular carcinoma have the same histology, appearing as single detached cells, as both have loss of expression of e-cadherin, the transmembrane protein mediating epithelial cell adhesion. LCIS often have the same genetic alterations (such as loss of heterozygosity on chromosome 16q, the locus for the e-cadherin gene) as the adjacent area of invasive carcinoma.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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