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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク LF22-0542 ： ウィキペディア英語版 LF22-0542 Chembox | ImageFile = LF 22-0542.svg | ImageSize = 200px | ImageAlt = | IUPACName = ''N''-methyl]-2-(HREF="http://www.kotoba.ne.jp/word/11/(4-methoxy-2,6-dimethylphenyl) sulfonyl )methylamino]ethoxy]-''N''-methylacetamide " TITLE="(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-''N''-methylacetamide "> OtherNames = antagonist. It displayed binding Ki values of 0.35 and 6.5 nM at cloned human and mouse B1 receptors, respectively, while having no affinity for either human, mouse, or rat B2 receptors at concentrations up to 10 μM. This means that LF22-0542 is at least 4000 times selective for the B1 receptor over the B2 receptor. Systemic administration of LF22-0542 inhibited acute pain induced by acetic acid, formalin, and a hot plate. It also reversed acute inflammatory pain induced by carrageenan, and persistent inflammatory pain induced by CFA. In a neuropathic pain model, LF22-0542 reversed the thermal ()], but not the mechanical hyperalgesia.〔cite journal|last=Porreca|first=Frank|title=Antinociceptive Pharmacology of N-()methyl]-2-ethoxy]-N-methylacetamide, Fumarate (LF22-0542), a Novel Nonpeptidic Bradykinin B1 Receptor Antagonist|journal=The Journal of Pharmacology and Experimental Therapeutics|date=July 2006|volume=318|issue=1|pages=195–205|doi=10.1124/jpet.105.098368|pmid=16565167|accessdate=18 December 2011}}〕 ==References== Category:Anti-inflammatory agents Category:Sulfonamides Category:Imidazolines 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「LF22-0542」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.