翻訳と辞書 |
LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A orphan receptor proteins. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. == Gene ==
Prior to its current naming designation, LGR5 was also known as FEX, HG38, GPR49, and GPR67.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8549 )〕 The Human LGR5 gene is 144,810 bases long and located at chromosome 12 at position 12q22-q23.〔Both human, rat and mouse homologs contain 907 amino acids and seven transmembrane domains.〔(【引用サイトリンク】 url = http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?familyId=16&objectId=148 )〕 After translation, the signal peptide (amino acids 1-21) is cleaved off and the mature peptide (amino acids 22-907) inserts its transmembrane domain into the translocon membrane prior to packaging towards the plasma membrane.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「LGR5」の詳細全文を読む
スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|