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LINGO1
Leucine rich repeat and Immunoglobin-like domain-containing protein 1〔(【引用サイトリンク】 url = http://www.uniprot.org/uniprot/Q96FE5 )〕 also known as LINGO-1 is a protein which is encoded by the ''LINGO1'' gene in humans.〔(【引用サイトリンク】 work = Entrez Gene )〕 It belongs to the family of leucine-rich repeat proteins which are known for playing key roles in the biology of the central nervous system. LINGO-1 is a functional component of the Nogo (neurite outgrowth inhibitor) receptor also known as the reticulon 4 receptor. It has been found that LINGO-1 antagonists such as BIIB033 could significantly improve and regulate survival after neural injury caused by the protein.
== Structure ==
The human LINGO-1 is a single-pass type 1 transmembrane protein of 614 amino acids. It contains a signal sequence of 34 residues, followed by a LRR (leucine-rich repeat) domain, an Ig (immunoglobulin-like) domain, a stalk domain, a transmembrane region and a short cytoplasmic tail. As a transmembrane protein, it can mostly be found on the cell membrane.
The LINGO-1 structure has been shown to be highly stable both in its crystal form and in solution, thanks to its leucine-rich repeat Ig-composite fold. Since the tetramer has a very large surface area into the cell membrane, it is thought that this may serve as an efficient and stable binding platform, facilitating the interaction with NgR, p75, TROY complex.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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