翻訳と辞書 ・ Ly Kim Leang
・ Ly line
・ Ly Son
・ Ly Thai Hung
・ Ly Thuch
・ Ly Tong
・ LY-215,840
・ LY-2183240
・ LY-235,959
・ LY-255582
・ LY-272,015
・ LY-293284
・ LY-2940094
・ LY-307,452
・ LY-310762
・ LY-320,135
・ LY-334370
・ LY-341,495
・ LY-344,545
・ LY-367,265
・ LY-379,268
・ LY-404,039
・ LY-404,187
・ LY-487,379
・ LY-503,430
・ LY-60 / FD-60 / PL10
・ Ly-Cilph
・ Ly-Fontaine
・ LY2181308
・ LY294002
|
|
LY-320,135
LY-320,135 is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor CB1. It was developed by Eli Lilly and Company in the 1990s.
LY-320,135 displays fairly good selectivity, with a binding affinity for CB1 around 70x stronger than for CB2,〔Felder CC, Joyce KE, Briley EM, Glass M, Mackie KP, Fahey KJ, Cullinan GJ, Hunden DC, Johnson DW, Chaney MO, Koppel GA, Brownstein M. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. ''Journal of Pharmacology and Experimental Therapeutics''. 1998 Jan;284(1):291-7. PMID 9435190〕 but both its potency and selectivity are modest compared to newer agents, and at higher doses it also binds to a range of non-cannabinoid receptors. However LY-320,135 is still fairly widely used in research, particularly for elucidating the mechanisms by which many CB1 antagonists act as inverse agonists at higher doses.〔Pertwee RG. Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. ''Life Sciences''. 2005 Feb 4;76(12):1307-24. PMID 15670612〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「LY-320,135」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|